Copper-catalyzed intermolecular C(sp3)–H bond functionalization towards the synthesis of tertiary carbamates† †Dedicated to Professor Iwao Ojima on his 70th birthday. ‡ ‡Electronic supplementary information (ESI) available: Experimental procedures, characterization data, and 1H and 13C NMR charts. See DOI: 10.1039/c5sc00238a
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Copper-catalyzed intermolecular C(sp3)-H bond functionalization towards the synthesis of tertiary carbamates.
We describe the development of an intermolecular unactivated C(sp3)-H bond functionalization towards the direct synthesis of tertiary carbamates. The transformation proceeded using a readily available, abundant first-row transition metal catalyst (copper), and isocyanates as the source of the amide moiety. This is a novel strategy for direct transformation of a variety of unactivated hydrocarbo...
متن کاملPalladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C(sp3)–H bonds with acetonitrile† †Electronic supplementary information (ESI) available: Experimental details including characterization data, copies of 1H, 13C NMR and NOESY spectra. See DOI: 10.1039/c5sc04066c Click here for additional data file.
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متن کاملCopper-catalyzed direct alkylation of heteroarenes† †Electronic supplementary information (ESI) available: Experimental procedures, characterization and copies of 1H and 13C NMR spectra for all new compounds. See DOI: 10.1039/c6sc05622a Click here for additional data file.
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Fluorine teams up with water to restore inhibitor activity to mutant BPTI† †Dedicated to Professor Iwao Ojima on the Occasion of his 70th Birthday. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c4sc03227f Click here for additional data file.
Shijie Ye1, Bernhard Loll2, Allison Ann Berger1, Ulrike Mülow1, Claudia Alings2, Markus Christian Wahl2 and Beate Koksch1* Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, 1. Institute of Chemistry and Biochemistry – Organic Chemistry, Takustrasse 3, 2. Institute of Chemistry and Biochemistry – Structural Biochemistry, Takustrasse 6, D-14195, Berlin, Germany *Correspond...
متن کاملTertiary amine synthesis via reductive coupling of amides with Grignard reagents† †Electronic supplementary information (ESI) available: Experimental procedures, spectroscopic data, copies of 1H and 13C NMR spectra and crystallographic data. CCDC 1552384. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc03613b Click here for additional data file. Click here for additional data file.
A new iridium catalyzed reductive coupling reaction of Grignard reagents and tertiary amides affording functionalised tertiary amine products via an efficient and technically-simple one-pot, two-stage experimental protocol, is reported. The reaction – which can be carried out on gram-scale using as little as 1 mol% Vaska's complex [IrCl(CO)(PPh3)2] and TMDS as the terminal reductant for the ini...
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عنوان ژورنال:
دوره 6 شماره
صفحات -
تاریخ انتشار 2015